Full Text Available
Note: Clicking the button above will open the full text document at the original institutional repository in a new window.
A study of different clinical and biochemical parameters in polycystic ovary syndrome affecting ovulation induction outcome and fertility potential
Thesis (DMed (Obstetrics and Gynaecology))--Stellenbosch University, 2008.
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Stellenbosch : Stellenbosch University
2008
|
| Subjects: | |
| Tags: |
No Tags, Be the first to tag this record!
|
| _version_ | 1867613768372977664 |
|---|---|
| access_status_str | Open Access |
| author | Siebert, T. I. |
| author2 | Kruger, T. F. |
| author_browse | Kruger, T. F. Siebert, T. I. |
| author_facet | Kruger, T. F. Siebert, T. I. |
| author_sort | Siebert, T. I. |
| collection | Thesis |
| dc_rights_str_mv | Stellenbosch University |
| description | Thesis (DMed (Obstetrics and Gynaecology))--Stellenbosch University, 2008. |
| format | Thesis |
| id | oai:scholar.sun.ac.za:10019.1/4076 |
| institution | Stellenbosch University (South Africa) |
| language | English |
| last_indexed | 2026-06-10T12:41:23.238Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from SUNScholar — Stellenbosch University Repository |
| publishDate | 2008 |
| publishDateRange | 2008 |
| publishDateSort | 2008 |
| publisher | Stellenbosch : Stellenbosch University |
| publisherStr | Stellenbosch : Stellenbosch University |
| record_format | dspace |
| source_str | SUNScholar — Stellenbosch University Repository |
| spelling | oai:scholar.sun.ac.za:10019.1/4076 A study of different clinical and biochemical parameters in polycystic ovary syndrome affecting ovulation induction outcome and fertility potential Siebert, T. I. Kruger, T. F. Stellenbosch University. Faculty of Health Sciences. Dept. of Obstetrics and Gynaecology. PCOS Ovulation induction Metformin Dissertations -- Obstetrics and gynaecology Theses -- Obstetrics and gynaecology Thesis (DMed (Obstetrics and Gynaecology))--Stellenbosch University, 2008. Chapter 1 presents a literature study on the diagnostic debate of PCOS. The literature study includes a discussion of the recent Rotterdam consensus statement regarding the diagnosis of PCOS. This is followed by a discussion on the essential work-up of the patient presenting with PCOS. Finally, chapter 1 presents a discussion on the complexity of the different variations in women presenting with PCOS. Chapter 2 is a literature review on ovulation induction methods in patients who present with PCOS. This literature study puts special emphasis on the different available methods used for ovulation induction in women with PCOS and the profounding effect weight loss will have in managing these patients. This chapter also addresses the use of newer agents, like aromatase inhibitors (Letrozole), and the current role of each of these agents in ovulation induction protocols. Chapter 3 is a literature overview on the effect of Metformin in Clomiphene-resistant PCOS women. The inclusion criteria of this review was all prospective randomized trials where Metformin was added for ovulation in the Clomiphene-resistant PCOS patient. The data is presented as a metaanalysis. Chapter 4 is a prospective randomise control trial to evaluate the benefit of metformin if added to Clomiphene in a primary ovulation induction protocol in comparison to Clomiphene alone. This chapter also evaluates all factors influencing ovulation outcome. Finally in the discussion section all the recent studies published addressing this topic were reviewed. Chapter 5 is a literature review to evaluate the classification systems for semen parameters and the in vivo fertility potential. This data is also used to establish fertility/subfertility thresholds for semen parameters. This chapter also presents the results of a prospective and retrospective study of the semen analysis of the partners of women with PCOS. We believe that this population presents the best reference group to study the semen profile of the general male population. Chapter 6 is a summary of the results of these studies and serves as an evidence based approach for ovulation induction in women with PCOS. Doctoral 2008-12-03T07:55:23Z 2010-08-13T13:12:09Z 2008-12-03T07:55:23Z 2010-08-13T13:12:09Z 2008-12 Thesis http://hdl.handle.net/10019.1/4076 en Stellenbosch University application/pdf Stellenbosch : Stellenbosch University |
| spellingShingle | PCOS Ovulation induction Metformin Dissertations -- Obstetrics and gynaecology Theses -- Obstetrics and gynaecology Siebert, T. I. A study of different clinical and biochemical parameters in polycystic ovary syndrome affecting ovulation induction outcome and fertility potential |
| title | A study of different clinical and biochemical parameters in polycystic ovary syndrome affecting ovulation induction outcome and fertility potential |
| title_full | A study of different clinical and biochemical parameters in polycystic ovary syndrome affecting ovulation induction outcome and fertility potential |
| title_fullStr | A study of different clinical and biochemical parameters in polycystic ovary syndrome affecting ovulation induction outcome and fertility potential |
| title_full_unstemmed | A study of different clinical and biochemical parameters in polycystic ovary syndrome affecting ovulation induction outcome and fertility potential |
| title_short | A study of different clinical and biochemical parameters in polycystic ovary syndrome affecting ovulation induction outcome and fertility potential |
| title_sort | study of different clinical and biochemical parameters in polycystic ovary syndrome affecting ovulation induction outcome and fertility potential |
| topic | PCOS Ovulation induction Metformin Dissertations -- Obstetrics and gynaecology Theses -- Obstetrics and gynaecology |
| url | http://hdl.handle.net/10019.1/4076 |
| work_keys_str_mv | AT siebertti astudyofdifferentclinicalandbiochemicalparametersinpolycysticovarysyndromeaffectingovulationinductionoutcomeandfertilitypotential AT siebertti studyofdifferentclinicalandbiochemicalparametersinpolycysticovarysyndromeaffectingovulationinductionoutcomeandfertilitypotential |