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The interaction between human spermatozoa and its homologous zona pellucida : scientific advances and clinical significance
Thesis (PhD)--Stellenbosch University, 2002.
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| Format: | Thesis |
| Language: | en_ZA |
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Stellenbosch : Stellenbosch University
2012
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| _version_ | 1867613744489562112 |
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| access_status_str | Open Access |
| author | Oehninger, Sergio C. |
| author2 | Franken, D. R. |
| author_browse | Franken, D. R. Oehninger, Sergio C. |
| author_facet | Franken, D. R. Oehninger, Sergio C. |
| author_sort | Oehninger, Sergio C. |
| collection | Thesis |
| dc_rights_str_mv | Stellenbosch University |
| description | Thesis (PhD)--Stellenbosch University, 2002. |
| format | Thesis |
| id | oai:scholar.sun.ac.za:10019.1/53132 |
| institution | Stellenbosch University (South Africa) |
| language | en_ZA |
| last_indexed | 2026-06-10T12:41:00.939Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from SUNScholar — Stellenbosch University Repository |
| publishDate | 2012 |
| publishDateRange | 2012 |
| publishDateSort | 2012 |
| publisher | Stellenbosch : Stellenbosch University |
| publisherStr | Stellenbosch : Stellenbosch University |
| record_format | dspace |
| source_str | SUNScholar — Stellenbosch University Repository |
| spelling | oai:scholar.sun.ac.za:10019.1/53132 The interaction between human spermatozoa and its homologous zona pellucida : scientific advances and clinical significance Oehninger, Sergio C. Franken, D. R. Stellenbosch University. Faculty of Medicine & Health Sciences . Dept. of Obstetrics & Gynaecology. Infertility, Male Human reproductive technology Zona pellucida Spermatozoa Dissertations -- Obstetrics and gynaecology Theses -- Obstetrics and gynaecology Theses -- Medicine Dissertations -- Medicine Thesis (PhD)--Stellenbosch University, 2002. ENGLISH ABSTRACT: Infertility is a very common problem worldwide. Recent data have shown that disorders of the male represent the most common single defined cause of infertility. This proposal examines the clinical significance and fundamental physiological aspects of human gamete interaction. These studies are focused on the assessment of the cellular-molecular mechanisms involved in human sperm binding to its homologous zona pellucida resulting in the physiologic induction of the acrosome reaction. We have developed and validated in vitro bioassays that assess specific steps of the fertilization process that are critical for early embryo development. The results of our translational research have already had a significant impact on the overall evaluation of male infertility and on the clinical management of the infertile man in the assisted reproduction arena. Furthermore, the unveiling of the basic mechanisms involved in human gamete interaction will ultimately allow for both (i) the development of new male reproductive diagnostic capabilities and (ii) the design of improved and safer therapies aiding conception in childless couples suffering from male infertility. AFRIKAANSE OPSOMMING: Menslike onvrugbaarheid is 'n algemene wêreldwye probleem en onlangse data toon aan dat die manlike factor die grootste enkel bydraende factor tot hierdie toestand is. Die werk loods 'n intensiewe ondersoek na die kliniese betekenis en basiese fisiologiese aspekte wat 'n rol tydens spermsel en eisel interaksie speel. Hoofstuk 3 fokus op die sellulêre en molekulêre meganismes wat betrokke is tydens spermsel en eisel binding wat gevolglik lei tot akrosoomreaksie van die spermsel. Die werk verteenwoordig die resultate van 10 jaar se navorsing tussen die kandidaat en die promoter. Dit gee oorsprong aan 'n reeks bio-toetse wat die bevrugtingsproses koriografiese ontleed en verskaf dus 'n stap-vir-stap uiteenseting van menslike bevrugting en gevolglike embrio ontwikkeling. Die resultate in Hoostuk 4 bring vernuwing in die begrippe van die manlike faktor en die rol in die kinderlose huwelik. Die resulate soos in Hoofstuk 3 en 4 uiteengesit, vorm nie net die basis vir die moontlike ontwikkeling van nuwe diagnostiese benaderings tot die hantering van die man nies maar speel oojk 'n rol die daarstelling van verbeterde terapeutiese hantering van die kinderlose egpaar. Hoofstuk 5 gee kortliks riglyne en aanbevelings tot opsigte van die gebruik van die spermsel-zona pellucida bindingstoets en akrosomreaksie. Die kandidaat bevel aan dat die genoemde twee bio-toetse deel van die laboratorium ondersoeke van die man gebruik moet word. Doctoral 2012-08-27T11:35:18Z 2012-08-27T11:35:18Z 2002-12 Thesis http://hdl.handle.net/10019.1/53132 en_ZA Stellenbosch University 247 p. : ill. application/pdf Stellenbosch : Stellenbosch University |
| spellingShingle | Infertility, Male Human reproductive technology Zona pellucida Spermatozoa Dissertations -- Obstetrics and gynaecology Theses -- Obstetrics and gynaecology Theses -- Medicine Dissertations -- Medicine Oehninger, Sergio C. The interaction between human spermatozoa and its homologous zona pellucida : scientific advances and clinical significance |
| title | The interaction between human spermatozoa and its homologous zona pellucida : scientific advances and clinical significance |
| title_full | The interaction between human spermatozoa and its homologous zona pellucida : scientific advances and clinical significance |
| title_fullStr | The interaction between human spermatozoa and its homologous zona pellucida : scientific advances and clinical significance |
| title_full_unstemmed | The interaction between human spermatozoa and its homologous zona pellucida : scientific advances and clinical significance |
| title_short | The interaction between human spermatozoa and its homologous zona pellucida : scientific advances and clinical significance |
| title_sort | interaction between human spermatozoa and its homologous zona pellucida scientific advances and clinical significance |
| topic | Infertility, Male Human reproductive technology Zona pellucida Spermatozoa Dissertations -- Obstetrics and gynaecology Theses -- Obstetrics and gynaecology Theses -- Medicine Dissertations -- Medicine |
| url | http://hdl.handle.net/10019.1/53132 |
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