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The effect of some aromatic compounds on the physiology of the rat and on certain microorganisms
Thesis (MSc) -- University of Stellenbosch, 1996.
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| Format: | Thesis |
| Language: | English |
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Stellenbosch : Stellenbosch University
2012
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| _version_ | 1867613948574957568 |
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| access_status_str | Open Access |
| author | Esterhuyse, Adriaan Johannes |
| author2 | Du Plessis, D. |
| author_browse | Du Plessis, D. Esterhuyse, Adriaan Johannes |
| author_facet | Du Plessis, D. Esterhuyse, Adriaan Johannes |
| author_sort | Esterhuyse, Adriaan Johannes |
| collection | Thesis |
| dc_rights_str_mv | Stellenbosch University |
| description | Thesis (MSc) -- University of Stellenbosch, 1996. |
| format | Thesis |
| id | oai:scholar.sun.ac.za:10019.1/55269 |
| institution | Stellenbosch University (South Africa) |
| language | English |
| last_indexed | 2026-06-10T12:44:15.221Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from SUNScholar — Stellenbosch University Repository |
| publishDate | 2012 |
| publishDateRange | 2012 |
| publishDateSort | 2012 |
| publisher | Stellenbosch : Stellenbosch University |
| publisherStr | Stellenbosch : Stellenbosch University |
| record_format | dspace |
| source_str | SUNScholar — Stellenbosch University Repository |
| spelling | oai:scholar.sun.ac.za:10019.1/55269 The effect of some aromatic compounds on the physiology of the rat and on certain microorganisms Esterhuyse, Adriaan Johannes Du Plessis, D. Hugo, V. I. Stellenbosch University. Faculty of Science. Dept. of Physiological Sciences. Tumors Liquid chromatography Quinone Rats as laboratory animals Aromatic compounds -- Physiological effect Microorganisms -- Effect of antibiotics on Dissertations -- Physiology (Human and animal) Thesis (MSc) -- University of Stellenbosch, 1996. Some quinones which show antibiotic activity contain a 2,3-[c] pyran ring as part of their structure. Bioreductive activation of the alkylating potential of several synthetic and naturally occurring quinones has been implicated in the antitumour activity of such compounds. These agents are believed to cross-link the complementary strands of cellular deoxyribonucleic acid, thereby inhibiting tumour growth as well as multiplication of microorganisms.A number of quinones was synthesised in the Department of Chemistry at the Cape Technikon and evaluated for antimicrobial activity. A rat model was used to evaluate their stability in vivo using a high performance liquid chromatographic (HPLC) technique. In the case of Demethoxyisoeleutherin, it was further evaluated in vivo for toxicological and biochemical effects. The results indicated that this quinone is active against several selected Gram positive organisms and HPLC results showed that it is also relatively stable in vivo. Some haematological changes were however recorded after repeated administration. For example, the increase in eosiniphil count may indicate an allergic reaction to the quinone and the release of anti-inflammatory substances. It was also established that this quinone causes a drop in pulse pressure of up to 25 %, mainly due to a decrease in systolic pressure.Micrographs were prepared from the histological slides of the kidneys, liver, spleen, stomach and small intestines of the test rats. Using a light optic microscope no abnormalities or tissue damage were indicated. Masters 2012-08-27T11:36:58Z 2012-08-27T11:36:58Z 1996 Thesis http://hdl.handle.net/10019.1/55269 en Stellenbosch University 123 pages : ill. application/pdf Stellenbosch : Stellenbosch University |
| spellingShingle | Tumors Liquid chromatography Quinone Rats as laboratory animals Aromatic compounds -- Physiological effect Microorganisms -- Effect of antibiotics on Dissertations -- Physiology (Human and animal) Esterhuyse, Adriaan Johannes The effect of some aromatic compounds on the physiology of the rat and on certain microorganisms |
| title | The effect of some aromatic compounds on the physiology of the rat and on certain microorganisms |
| title_full | The effect of some aromatic compounds on the physiology of the rat and on certain microorganisms |
| title_fullStr | The effect of some aromatic compounds on the physiology of the rat and on certain microorganisms |
| title_full_unstemmed | The effect of some aromatic compounds on the physiology of the rat and on certain microorganisms |
| title_short | The effect of some aromatic compounds on the physiology of the rat and on certain microorganisms |
| title_sort | effect of some aromatic compounds on the physiology of the rat and on certain microorganisms |
| topic | Tumors Liquid chromatography Quinone Rats as laboratory animals Aromatic compounds -- Physiological effect Microorganisms -- Effect of antibiotics on Dissertations -- Physiology (Human and animal) |
| url | http://hdl.handle.net/10019.1/55269 |
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