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Evaluation of free radical damage to myocardial membranes in ischaemia and reperfusion
Thesis (M.Sc.(Med.Biochem.)) -- University of Stellenbosch, 1990.
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| Other Authors: | |
| Format: | Thesis |
| Language: | en_ZA |
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Stellenbosch : Stellenbosch University
2012
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| _version_ | 1867613805757857792 |
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| access_status_str | Open Access |
| author | Coetzee, Isabella H. |
| author2 | Lochner, Amanda |
| author_browse | Coetzee, Isabella H. Lochner, Amanda |
| author_facet | Lochner, Amanda Coetzee, Isabella H. |
| author_sort | Coetzee, Isabella H. |
| collection | Thesis |
| dc_rights_str_mv | Stellenbosch University |
| description | Thesis (M.Sc.(Med.Biochem.)) -- University of Stellenbosch, 1990. |
| format | Thesis |
| id | oai:scholar.sun.ac.za:10019.1/57753 |
| institution | Stellenbosch University (South Africa) |
| language | en_ZA |
| last_indexed | 2026-06-10T12:41:59.323Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from SUNScholar — Stellenbosch University Repository |
| publishDate | 2012 |
| publishDateRange | 2012 |
| publishDateSort | 2012 |
| publisher | Stellenbosch : Stellenbosch University |
| publisherStr | Stellenbosch : Stellenbosch University |
| record_format | dspace |
| source_str | SUNScholar — Stellenbosch University Repository |
| spelling | oai:scholar.sun.ac.za:10019.1/57753 Evaluation of free radical damage to myocardial membranes in ischaemia and reperfusion Coetzee, Isabella H. Lochner, Amanda Stellenbosch University. Faculty of Medicine and Health Sciences. Dept. of Biomedical Sciences. Division of Medical Physiology. Myocardium Ischemia Dissertations -- Medicine Thesis (M.Sc.(Med.Biochem.)) -- University of Stellenbosch, 1990. Several experimental studies now exist indicating that oxygen radicals contribute to Mycardial damage in ischaemia and reperfusion. The majority of these studies provided indirect evidence of oxygen radical involvement by using radical scavengers or specific enzymes (e.g. catalase, superoxide dismutase). Recent studies, using electron spin resonance, provided direct evidence of a "burst" of free radical generation especially during reperfusion. Whether generation of free radicals during ischaemia alone is solely responsible for the membrane changes characteristic of myocardial ischaemia, remains to be established. The aim of this study was therefore to compare the well-known ischaemia-induced membrane changes with those produced by an in vitro free radical attack on either isolated myocardial membranes or the perfused rat heart. Masters 2012-08-27T11:38:38Z 2012-08-27T11:38:38Z 1990 Thesis http://hdl.handle.net/10019.1/57753 en_ZA Stellenbosch University 162 pages : ill. application/pdf Stellenbosch : Stellenbosch University |
| spellingShingle | Myocardium Ischemia Dissertations -- Medicine Coetzee, Isabella H. Evaluation of free radical damage to myocardial membranes in ischaemia and reperfusion |
| title | Evaluation of free radical damage to myocardial membranes in ischaemia and reperfusion |
| title_full | Evaluation of free radical damage to myocardial membranes in ischaemia and reperfusion |
| title_fullStr | Evaluation of free radical damage to myocardial membranes in ischaemia and reperfusion |
| title_full_unstemmed | Evaluation of free radical damage to myocardial membranes in ischaemia and reperfusion |
| title_short | Evaluation of free radical damage to myocardial membranes in ischaemia and reperfusion |
| title_sort | evaluation of free radical damage to myocardial membranes in ischaemia and reperfusion |
| topic | Myocardium Ischemia Dissertations -- Medicine |
| url | http://hdl.handle.net/10019.1/57753 |
| work_keys_str_mv | AT coetzeeisabellah evaluationoffreeradicaldamagetomyocardialmembranesinischaemiaandreperfusion |