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Aspects of the pharmacokinetics of hypoxoside in rodents
Thesis (M. Sc.(Med.)) -- University of Stellenbosch, 1993.
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| Format: | Thesis |
| Language: | en_ZA |
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Stellenbosch : Stellenbosch University
2012
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| _version_ | 1867613910698295296 |
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| access_status_str | Open Access |
| author | Bester, Christoffel Carolus |
| author2 | Stellenbosch University. Faculty of Medicine and Health Sciences. Dept. of Medical Microbiology. |
| author_browse | Bester, Christoffel Carolus Stellenbosch University. Faculty of Medicine and Health Sciences. Dept. of Medical Microbiology. |
| author_facet | Stellenbosch University. Faculty of Medicine and Health Sciences. Dept. of Medical Microbiology. Bester, Christoffel Carolus |
| author_sort | Bester, Christoffel Carolus |
| collection | Thesis |
| dc_rights_str_mv | Stellenbosch University |
| description | Thesis (M. Sc.(Med.)) -- University of Stellenbosch, 1993. |
| format | Thesis |
| id | oai:scholar.sun.ac.za:10019.1/57866 |
| institution | Stellenbosch University (South Africa) |
| language | en_ZA |
| last_indexed | 2026-06-10T12:43:39.397Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from SUNScholar — Stellenbosch University Repository |
| publishDate | 2012 |
| publishDateRange | 2012 |
| publishDateSort | 2012 |
| publisher | Stellenbosch : Stellenbosch University |
| publisherStr | Stellenbosch : Stellenbosch University |
| record_format | dspace |
| source_str | SUNScholar — Stellenbosch University Repository |
| spelling | oai:scholar.sun.ac.za:10019.1/57866 Aspects of the pharmacokinetics of hypoxoside in rodents Bester, Christoffel Carolus Stellenbosch University. Faculty of Medicine and Health Sciences. Dept. of Medical Microbiology. Pharmacokinetics Rodents as laboratory animals Dissertations -- Medicine Thesis (M. Sc.(Med.)) -- University of Stellenbosch, 1993. ENGLISH ABSTRACT: Certain aspects of the pharmacokinetics of a novel diglucoside, hypoxoside, were investigated in mice and rats. After intragastric dosage of the mouse, hypoxoside was hydrolysed to its aglycone, rooperol. Most enzyme activity occurred in the mouse caecum with intestinal bacteria playing a major role in producing the hydrolytic enzymes. Caecalase extracts hydrolysed hypoxoside in vitro but this activity ceased after the mice were treated with antibiotics, suggesting bacteria as the enzyme source. However, in vivo tests with similar antibiotic-treated mice seemed to demonstrate a minor second, possibly mucosal source of hypoxoside hydrolysing B-glucosidase. An attempt to isolate a single strain of faecal bacteria capable of this activity was unsuccessful although hypoxoside was hydrolysed by pure cultures of some non-intestinal clinical isolates AFRIKAANSE OPSOMMING: Sekere aspekte van die farmakokinetika van 'n nuwe diglukosied, hipoksosied, was ondersoek deur gebruik te maak van muise en rotte. Na intragastriese dosering van muise word hipoksosied na sy aglikon, rooperol gehidroliseer. Die meeste ensiemaktiwiteit he tin die muissekum plaasgevind waar intestinale bakterieë 'n vername rol speel in die produksie van die hidrolitiese ensieme. Sekalase ekstrakte het hipoksosied in vitro gehidroliseer maar hierdie proses het ten einde gekom na behandeling van die muise met antibiotika. Dit wil dus voorkom asof bakterieë die bron van die ensiem is. In vivo toetse met soortgelyke behandelde muise, dui op die bestaan van 'n tweede, moontlik mukosale, bron van die ensiem. 'n Poging om 'n reinkultuur van fekale bakterië te isoleer wat in staat was om hipoksosied te hidroliseer was onsuksesvol, alhoewel reinkulture van sekere nie-intestinale kliniese isolate dit wel kon doen. 2012-08-27T11:38:42Z 2012-08-27T11:38:42Z 1993 Thesis http://hdl.handle.net/10019.1/57866 en_ZA Stellenbosch University 159 pages application/pdf Stellenbosch : Stellenbosch University |
| spellingShingle | Pharmacokinetics Rodents as laboratory animals Dissertations -- Medicine Bester, Christoffel Carolus Aspects of the pharmacokinetics of hypoxoside in rodents |
| title | Aspects of the pharmacokinetics of hypoxoside in rodents |
| title_full | Aspects of the pharmacokinetics of hypoxoside in rodents |
| title_fullStr | Aspects of the pharmacokinetics of hypoxoside in rodents |
| title_full_unstemmed | Aspects of the pharmacokinetics of hypoxoside in rodents |
| title_short | Aspects of the pharmacokinetics of hypoxoside in rodents |
| title_sort | aspects of the pharmacokinetics of hypoxoside in rodents |
| topic | Pharmacokinetics Rodents as laboratory animals Dissertations -- Medicine |
| url | http://hdl.handle.net/10019.1/57866 |
| work_keys_str_mv | AT besterchristoffelcarolus aspectsofthepharmacokineticsofhypoxosideinrodents |