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Free radical damage to chromatin
Thesis (PhD)--University of Stellenbosch, 1993.
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| Format: | Thesis |
| Language: | en_ZA |
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Stellenbosch : Stellenbosch University
2012
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| _version_ | 1867613957732171776 |
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| access_status_str | Open Access |
| author | Nackerdien, Zeena Elnisa |
| author2 | Bohm, Lothar |
| author_browse | Bohm, Lothar Nackerdien, Zeena Elnisa |
| author_facet | Bohm, Lothar Nackerdien, Zeena Elnisa |
| author_sort | Nackerdien, Zeena Elnisa |
| collection | Thesis |
| dc_rights_str_mv | Stellenbosch University |
| description | Thesis (PhD)--University of Stellenbosch, 1993. |
| format | Thesis |
| id | oai:scholar.sun.ac.za:10019.1/57987 |
| institution | Stellenbosch University (South Africa) |
| language | en_ZA |
| last_indexed | 2026-06-10T12:44:24.378Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from SUNScholar — Stellenbosch University Repository |
| publishDate | 2012 |
| publishDateRange | 2012 |
| publishDateSort | 2012 |
| publisher | Stellenbosch : Stellenbosch University |
| publisherStr | Stellenbosch : Stellenbosch University |
| record_format | dspace |
| source_str | SUNScholar — Stellenbosch University Repository |
| spelling | oai:scholar.sun.ac.za:10019.1/57987 Free radical damage to chromatin Nackerdien, Zeena Elnisa Bohm, Lothar Dizdaroglu, M. Stellenbosch University. Faculty of Medicine and Health Sciences. Department of Biomedical Sciences: Molecular Biology and Human Genetics Chromatin Dissertations -- Medicine UCTD Thesis (PhD)--University of Stellenbosch, 1993. ENGLISH ABSTRACT: Oxygen-derived free radicals are implicated in many human diseases including cancer. The mutagenic and carcinogenic properties of these species manifest themselves in lingering damage to several biomolecules including DNA. Here, efforts have been made to chemically characterize DNA base damage and DNA-protein cross-links produced in isolated chromatin and in cultured mammalian cells exposed to ionizing radiation or to H2O2/metal ions. Gas chromatography/mass spectrometry with selected ion-monitoring was used for this purpose. AFRIKAANSE OPSOMMING: Vry radikaal derivate van suurstof word geimpliseer in verskeie siektes insluitende kanker. Mutasies en kankerwekkende eienskappe van hierdie spesies word geopenbaar deur langdurige skade aan verskeie biomolekules insluitende DNS. Geisoleerde kromatien sowel as kromatien afkomstig van gekultureerde soogdier selle is hier ionies bestraal of behandel met H2O2/metaal ione. Chemiese skade berokken aan DNS basisse en DNS-protein kruisverbindings is met behulp van gas chromotografie/massa spektrometrie (insluitende geselekteerde ion-waarneming) gemonitor. Doctoral 2012-08-27T11:38:45Z 2012-08-27T11:38:45Z 1993-03 Thesis http://hdl.handle.net/10019.1/57987 en_ZA Stellenbosch University 124 pages application/pdf Stellenbosch : Stellenbosch University |
| spellingShingle | Chromatin Dissertations -- Medicine UCTD Nackerdien, Zeena Elnisa Free radical damage to chromatin |
| title | Free radical damage to chromatin |
| title_full | Free radical damage to chromatin |
| title_fullStr | Free radical damage to chromatin |
| title_full_unstemmed | Free radical damage to chromatin |
| title_short | Free radical damage to chromatin |
| title_sort | free radical damage to chromatin |
| topic | Chromatin Dissertations -- Medicine UCTD |
| url | http://hdl.handle.net/10019.1/57987 |
| work_keys_str_mv | AT nackerdienzeenaelnisa freeradicaldamagetochromatin |