Full Text Available
Note: Clicking the button above will open the full text document at the original institutional repository in a new window.
A study of the kindled rat model of epilepsy
Thesis (Ph.D.(Med.Sc.)) -- University of Stellenbosch, 1994.
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Stellenbosch : Stellenbosch University
2012
|
| Subjects: | |
| Tags: |
No Tags, Be the first to tag this record!
|
| _version_ | 1867614014603788288 |
|---|---|
| access_status_str | Open Access |
| author | Engelbrecht, Albertus Hermanus |
| author2 | Taljaard, J. J. F. |
| author_browse | Engelbrecht, Albertus Hermanus Taljaard, J. J. F. |
| author_facet | Taljaard, J. J. F. Engelbrecht, Albertus Hermanus |
| author_sort | Engelbrecht, Albertus Hermanus |
| collection | Thesis |
| dc_rights_str_mv | Stellenbosch University |
| description | Thesis (Ph.D.(Med.Sc.)) -- University of Stellenbosch, 1994. |
| format | Thesis |
| id | oai:scholar.sun.ac.za:10019.1/58280 |
| institution | Stellenbosch University (South Africa) |
| language | English |
| last_indexed | 2026-06-10T12:45:17.761Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from SUNScholar — Stellenbosch University Repository |
| publishDate | 2012 |
| publishDateRange | 2012 |
| publishDateSort | 2012 |
| publisher | Stellenbosch : Stellenbosch University |
| publisherStr | Stellenbosch : Stellenbosch University |
| record_format | dspace |
| source_str | SUNScholar — Stellenbosch University Repository |
| spelling | oai:scholar.sun.ac.za:10019.1/58280 A study of the kindled rat model of epilepsy Engelbrecht, Albertus Hermanus Taljaard, J. J. F. Russel, V. A. Stellenbosch University. Faculty of Medicine and Health Sciences. Dept. of Pathology. Division of Chemical Pathology. Epilepsy Epilepsy -- Research Dissertations -- Medicine Thesis (Ph.D.(Med.Sc.)) -- University of Stellenbosch, 1994. The aim of the present study was firstly to create a kindling-induced locus resembling the focal point in temporal lobe epilepsy. Secondly, it was necessary to determine the central neurotransmitter changes brought about by the kindling process, a phenomenon in which repeated administration of an initially subconvulsive electrical stimulus results in progressive intensification of seizure activity, culminating in a generalized seizure. In order to achieve these aims, the rotational behaviour of rats was determined and a pair of electrodes was implanted into the basolateral amygdala of the dominant hemisphere. Kindling was rated against a 5 point scale and was regarded as completed when the rat had displayed stage 5 seizures on 5 separate occasions. Sham kindled rats were treated identically except that electrical current was not applied to the electrodes. Unoperated rats served as additional controls. The kindling phenomenon of epilepsy provided the foundation needed to explore the underlying mechanisms. Distinction was made between rats killed 2 hours (short-term) or 28 days (long-term) after the fifth stage 5 seizure. Short-term results reflected changes induced by recent kindled seizures whereas long-term results provided information on the enduring changes which accompany the kindling process. Doctoral 2012-08-27T11:38:53Z 2012-08-27T11:38:53Z 1994-12 Thesis http://hdl.handle.net/10019.1/58280 en Stellenbosch University 258 pages application/pdf Stellenbosch : Stellenbosch University |
| spellingShingle | Epilepsy Epilepsy -- Research Dissertations -- Medicine Engelbrecht, Albertus Hermanus A study of the kindled rat model of epilepsy |
| title | A study of the kindled rat model of epilepsy |
| title_full | A study of the kindled rat model of epilepsy |
| title_fullStr | A study of the kindled rat model of epilepsy |
| title_full_unstemmed | A study of the kindled rat model of epilepsy |
| title_short | A study of the kindled rat model of epilepsy |
| title_sort | study of the kindled rat model of epilepsy |
| topic | Epilepsy Epilepsy -- Research Dissertations -- Medicine |
| url | http://hdl.handle.net/10019.1/58280 |
| work_keys_str_mv | AT engelbrechtalbertushermanus astudyofthekindledratmodelofepilepsy AT engelbrechtalbertushermanus studyofthekindledratmodelofepilepsy |