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Erythrocyte apoptosis (erythroptosis) and anaemia in chronic HIV-1 infection : relationship with immune activation and viraemia
Thesis (MScMedSc)-- Stellenbosch University, 2013.
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| Format: | Thesis |
| Language: | en_ZA |
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Stellenbosch : Stellenbosch University
2013
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| _version_ | 1867614098097700864 |
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| access_status_str | Open Access |
| author | Loots, Stanley |
| author2 | Glashoff, Richard H. |
| author_browse | Glashoff, Richard H. Loots, Stanley |
| author_facet | Glashoff, Richard H. Loots, Stanley |
| author_sort | Loots, Stanley |
| collection | Thesis |
| dc_rights_str_mv | Stellenbosch University |
| description | Thesis (MScMedSc)-- Stellenbosch University, 2013. |
| format | Thesis |
| id | oai:scholar.sun.ac.za:10019.1/85803 |
| institution | Stellenbosch University (South Africa) |
| language | en_ZA |
| last_indexed | 2026-06-10T12:46:38.139Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from SUNScholar — Stellenbosch University Repository |
| publishDate | 2013 |
| publishDateRange | 2013 |
| publishDateSort | 2013 |
| publisher | Stellenbosch : Stellenbosch University |
| publisherStr | Stellenbosch : Stellenbosch University |
| record_format | dspace |
| source_str | SUNScholar — Stellenbosch University Repository |
| spelling | oai:scholar.sun.ac.za:10019.1/85803 Erythrocyte apoptosis (erythroptosis) and anaemia in chronic HIV-1 infection : relationship with immune activation and viraemia Loots, Stanley Glashoff, Richard H. Ipp, Hayley Stellenbosch University. Faculty of Medicine and Health Sciences. Dept. of Pathology, Medical Virology. Erythrocyte apoptosis anaemia HIV Anaemia in chronic HIV-positive persons Theses -- Medicine Dissertations -- Medicine Theses -- Medical virology Dissertations -- Medical virology HIV (Viruses) Cell death Apoptosis HIV positive persons -- Anaemia Thesis (MScMedSc)-- Stellenbosch University, 2013. ENGLISH ABSTRACT: Chronic HIV-1 infection is characterized by extensive inflammation/immune activation and also by anaemia. Macrophages and neutrophils produce reactive oxygen species (ROS) which can cause damage to surrounding cells, including erythrocytes. Damaged erythrocytes may die by apoptosis (erythroptosis) or be tagged for clearance by monocytes/ macrophages. In this study we investigated HIV-1-associated anaemia and erythroptosis in asymptomatic, untreated HIV-1 infected individuals and how it relates to oxidative stress and immune activation. AFRIKAANSE OPSOMMING: Chroniese MIV-1 infeksie word gekenmerk deur uitgebreide inflammasie/immuun aktivering en ook deur anemie. Makrofage en neutrofiele produseer reaktiewe suurstof spesies (ROS), wat kan skade aan omliggende selle, insluitend rooibloedselle veroorsaak. Beskadigde rooibloedselle kan sterf deur apoptose (erythroptosis) of gemerk vir klaring deur monosiete/makrofage. In hierdie studie het ons ondersoek MIV-1-verwante bloedarmoede en erythroptosis in asimptomatiese, onbehandelde MIV-1 besmette individue en hoe dit verband hou met oksidatiewe stres en immuun aktivering. The Poliomyelitis Research Foundation (PRF 2013-11-28T05:27:35Z 2013-12-13T17:10:53Z 2013-11-28T05:27:35Z 2013-12-13T17:10:53Z 2013-12 Thesis http://hdl.handle.net/10019.1/85803 en_ZA Stellenbosch University xx, 89 p. : col. ill. application/pdf Stellenbosch : Stellenbosch University |
| spellingShingle | Erythrocyte apoptosis anaemia HIV Anaemia in chronic HIV-positive persons Theses -- Medicine Dissertations -- Medicine Theses -- Medical virology Dissertations -- Medical virology HIV (Viruses) Cell death Apoptosis HIV positive persons -- Anaemia Loots, Stanley Erythrocyte apoptosis (erythroptosis) and anaemia in chronic HIV-1 infection : relationship with immune activation and viraemia |
| title | Erythrocyte apoptosis (erythroptosis) and anaemia in chronic HIV-1 infection : relationship with immune activation and viraemia |
| title_full | Erythrocyte apoptosis (erythroptosis) and anaemia in chronic HIV-1 infection : relationship with immune activation and viraemia |
| title_fullStr | Erythrocyte apoptosis (erythroptosis) and anaemia in chronic HIV-1 infection : relationship with immune activation and viraemia |
| title_full_unstemmed | Erythrocyte apoptosis (erythroptosis) and anaemia in chronic HIV-1 infection : relationship with immune activation and viraemia |
| title_short | Erythrocyte apoptosis (erythroptosis) and anaemia in chronic HIV-1 infection : relationship with immune activation and viraemia |
| title_sort | erythrocyte apoptosis erythroptosis and anaemia in chronic hiv 1 infection relationship with immune activation and viraemia |
| topic | Erythrocyte apoptosis anaemia HIV Anaemia in chronic HIV-positive persons Theses -- Medicine Dissertations -- Medicine Theses -- Medical virology Dissertations -- Medical virology HIV (Viruses) Cell death Apoptosis HIV positive persons -- Anaemia |
| url | http://hdl.handle.net/10019.1/85803 |
| work_keys_str_mv | AT lootsstanley erythrocyteapoptosiserythroptosisandanaemiainchronichiv1infectionrelationshipwithimmuneactivationandviraemia |