Full Text Available
Note: Clicking the button above will open the full text document at the original institutional repository in a new window.
Modelling the dynamics of HIV related malignancies
Thesis (MSc)--Stellenbosch University, 2014.
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Thesis |
| Language: | en_ZA |
| Published: |
Stellenbosch : Stellenbosch University
2014
|
| Subjects: | |
| Tags: |
No Tags, Be the first to tag this record!
|
| _version_ | 1867613796732764160 |
|---|---|
| access_status_str | Open Access |
| author | Akinlotan, Deborah Morenikeji |
| author2 | Nyabadza, Farai |
| author_browse | Akinlotan, Deborah Morenikeji Nyabadza, Farai |
| author_facet | Nyabadza, Farai Akinlotan, Deborah Morenikeji |
| author_sort | Akinlotan, Deborah Morenikeji |
| collection | Thesis |
| dc_rights_str_mv | Stellenbosch University |
| description | Thesis (MSc)--Stellenbosch University, 2014. |
| format | Thesis |
| id | oai:scholar.sun.ac.za:10019.1/86573 |
| institution | Stellenbosch University (South Africa) |
| language | en_ZA |
| last_indexed | 2026-06-10T12:41:50.126Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from SUNScholar — Stellenbosch University Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Stellenbosch : Stellenbosch University |
| publisherStr | Stellenbosch : Stellenbosch University |
| record_format | dspace |
| source_str | SUNScholar — Stellenbosch University Repository |
| spelling | oai:scholar.sun.ac.za:10019.1/86573 Modelling the dynamics of HIV related malignancies Akinlotan, Deborah Morenikeji Nyabadza, Farai Stellenbosch University. Faculty of Science. Dept. of Mathematical Sciences. Theses -- Mathematics Dissertations -- Mathematics HIV infections -- Complications Cancer Lymphomas HIV infections -- Complications -- Mathematical models Cancer -- Mathematical models Lymphomas -- Mathematical models UCTD Thesis (MSc)--Stellenbosch University, 2014. ENGLISH ABSTRACT: In recent years, HIV-associated cancers have proven to be the bane of our time, since HIV is decimating humanity across the globe, even in the twilight of the last century. Cancer rates continue to rise in developing countries, where 95% of the world’s HIV-infected population lives, yet less than 1% have access to antiretroviral therapy. HIV-infected individuals have a higher proclivity to develop cancers, mainly from immunosuppression. An understanding of the immunopathogenesis of HIV-related cancers (HRC) is therefore a major prerequisite for rationally developing and/or improving therapeutic strategies, developing immunotherapeutics and proplylatic vaccines. In this study, we explore the pathology of HIV-related cancer malignancies, taking into account the pathogenic mechanisms and their potential for improving the treatment of management of these malignancies especially in developing countries. We mathematically model the dynamics of malignant tumors in an HIV-free environment, investigate the impact of cancer malignancies on HIV-positive patients and explore the benefits of various therapeutic intervention strategies in the management of HIV-related cancers. We present two deterministic models of infectious diseases to implement these, and they were analysed. We use HIV-related lymphomas in the Western Cape of South Africa as a case study. We validated the proposed models using lymphoma incidence data from the Tygerberg Lymphoma Study Group (TLSG), Tygerberg Hospital, Western Cape, South Africa. We show that the increasing prevalence of HIV increases lymphoma cases, and thus, other HIV-related cancers. Our models also suggests that an increase in the roll-out of the HAART program can reduce the number of lymphoma cases in the nearest future, while it averts many deaths. Furthermore, the results indicate that a highly crucial factor to consider in the prognosis of the incidence of lymphoma (and other cancer types) in HIV-infected patients is their CD4 cell count, irrespective of whether the patient has developed an HRC or not. 2014-04-16T17:30:06Z 2014-04-16T17:30:06Z 2014-04 Thesis http://hdl.handle.net/10019.1/86573 en_ZA Stellenbosch University 131 p. : ill. application/pdf Stellenbosch : Stellenbosch University |
| spellingShingle | Theses -- Mathematics Dissertations -- Mathematics HIV infections -- Complications Cancer Lymphomas HIV infections -- Complications -- Mathematical models Cancer -- Mathematical models Lymphomas -- Mathematical models UCTD Akinlotan, Deborah Morenikeji Modelling the dynamics of HIV related malignancies |
| title | Modelling the dynamics of HIV related malignancies |
| title_full | Modelling the dynamics of HIV related malignancies |
| title_fullStr | Modelling the dynamics of HIV related malignancies |
| title_full_unstemmed | Modelling the dynamics of HIV related malignancies |
| title_short | Modelling the dynamics of HIV related malignancies |
| title_sort | modelling the dynamics of hiv related malignancies |
| topic | Theses -- Mathematics Dissertations -- Mathematics HIV infections -- Complications Cancer Lymphomas HIV infections -- Complications -- Mathematical models Cancer -- Mathematical models Lymphomas -- Mathematical models UCTD |
| url | http://hdl.handle.net/10019.1/86573 |
| work_keys_str_mv | AT akinlotandeborahmorenikeji modellingthedynamicsofhivrelatedmalignancies |