Full Text Available
Note: Clicking the button above will open the full text document at the original institutional repository in a new window.
Clinical value of a uniform research case definition of tuberculous meningitis
Thesis (MMed)--Stellenbosch University, 2014.
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Thesis |
| Language: | en_ZA |
| Published: |
Stellenbosch : Stellenbosch University
2014
|
| Subjects: | |
| Tags: |
No Tags, Be the first to tag this record!
|
| _version_ | 1867614128578756608 |
|---|---|
| access_status_str | Open Access |
| author | Wessels, Marie |
| author2 | Solomons, Regan Shane |
| author_browse | Solomons, Regan Shane Wessels, Marie |
| author_facet | Solomons, Regan Shane Wessels, Marie |
| author_sort | Wessels, Marie |
| collection | Thesis |
| dc_rights_str_mv | Stellenbosch University |
| description | Thesis (MMed)--Stellenbosch University, 2014. |
| format | Thesis |
| id | oai:scholar.sun.ac.za:10019.1/86775 |
| institution | Stellenbosch University (South Africa) |
| language | en_ZA |
| last_indexed | 2026-06-10T12:47:07.138Z |
| license_str | Other — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from SUNScholar — Stellenbosch University Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Stellenbosch : Stellenbosch University |
| publisherStr | Stellenbosch : Stellenbosch University |
| record_format | dspace |
| source_str | SUNScholar — Stellenbosch University Repository |
| spelling | oai:scholar.sun.ac.za:10019.1/86775 Clinical value of a uniform research case definition of tuberculous meningitis Wessels, Marie Solomons, Regan Shane Stellenbosch University. Faculty of Medicine and Health Sciences. Dept. of Paediatrics and Child Health. Meningitis in children Meninges -- Tuberculosis -- Diagnosis Meninges -- Tuberculosis -- Treatment UCTD Thesis (MMed)--Stellenbosch University, 2014. ENGLISH ABSTRACT: BACKGROUND: Tuberculous meningitis (TBM) research remains important but obtaining adequate sample sizes of microbiologically-confirmed TBM cases is difficult, therefore clinical cases of TBM need to be included. A uniform research case definition for TBM was developed to assist diagnostic standardization. METHODS: Our study evaluated the proposed uniform research case definition in a group of children diagnosed with TBM. A subgroup of 66 children with cultureconfirmed TBM was compared to culture-confirmed bacterial meningitis controls. RESULTS: The uniform case definition was applied to 554 TBM patients. Sixty-six (11.9%) patients had definite TBM, 408 (73.6%) had probable TBM and 72 (13.0%) had possible TBM. Symptom duration >5 days, weight loss or persistent cough >2 weeks, recent TB contact, focal neurological deficit, clear cerebrospinal fluid (CSF) appearance and basal meningeal enhancement predicted TBM when compared to definite bacterial meningitis with a sensitivity and specificity of 97.0% and 93.7%, respectively. When using a probable TBM score as the diagnostic measure, sensitivity was 86% and specificity was 100%. When using a possible TBM score as the diagnostic measure, sensitivity was 100% but specificity was 56%. CONCLUSION: The uniform research case definition for TBM performed well when using a probable TBM score as the diagnostic marker. A regression model also differentiated TBM from bacterial meningitis with good accuracy, but caution is needed in its application to early TBM. 2014-04-16T17:33:31Z 2015-01-02T03:00:05Z 2014-04 Thesis http://hdl.handle.net/10019.1/86775 en_ZA Stellenbosch University 21 pages application/pdf application/pdf Stellenbosch : Stellenbosch University |
| spellingShingle | Meningitis in children Meninges -- Tuberculosis -- Diagnosis Meninges -- Tuberculosis -- Treatment UCTD Wessels, Marie Clinical value of a uniform research case definition of tuberculous meningitis |
| title | Clinical value of a uniform research case definition of tuberculous meningitis |
| title_full | Clinical value of a uniform research case definition of tuberculous meningitis |
| title_fullStr | Clinical value of a uniform research case definition of tuberculous meningitis |
| title_full_unstemmed | Clinical value of a uniform research case definition of tuberculous meningitis |
| title_short | Clinical value of a uniform research case definition of tuberculous meningitis |
| title_sort | clinical value of a uniform research case definition of tuberculous meningitis |
| topic | Meningitis in children Meninges -- Tuberculosis -- Diagnosis Meninges -- Tuberculosis -- Treatment UCTD |
| url | http://hdl.handle.net/10019.1/86775 |
| work_keys_str_mv | AT wesselsmarie clinicalvalueofauniformresearchcasedefinitionoftuberculousmeningitis |