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Safety and pharmacokinetics of GSK3494245, a highly selective Leishmaniasis kinetoplastid proteasome inhibitor for the treatment of visceral leishmaniasis: A Phase 1, randomized, single ascending dose escalation study in healthy participants
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| Published in: | PLOS Neglected Tropical Diseases Atom |
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| Format: | Online Article RSS Article |
| Published: |
2026
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| container_title | PLOS Neglected Tropical Diseases Atom |
| description | |
| discipline_display | Medical & Health Sciences |
| discipline_facet | Medical & Health Sciences |
| format | Online Article RSS Article |
| genre | Journal Article |
| id | rss_article:51561 |
| institution | FRELIP |
| journal_source_facet | PLOS Neglected Tropical Diseases Atom |
| publishDate | 2026 |
| publishDateSort | 2026 |
| record_format | rss_article |
| spellingShingle | Safety and pharmacokinetics of GSK3494245, a highly selective Leishmaniasis kinetoplastid proteasome inhibitor for the treatment of visceral leishmaniasis: A Phase 1, randomized, single ascending dose escalation study in healthy participants PLOS Neglected Tropical Diseases Atom Clinical Medicine Medical & Health Sciences |
| sub_discipline_display | Clinical Medicine |
| sub_discipline_facet | Clinical Medicine |
| subject_display | PLOS Neglected Tropical Diseases Atom Clinical Medicine Medical & Health Sciences PLOS Neglected Tropical Diseases Atom Clinical Medicine Medical & Health Sciences |
| subject_facet | PLOS Neglected Tropical Diseases Atom Clinical Medicine Medical & Health Sciences |
| title | Safety and pharmacokinetics of GSK3494245, a highly selective Leishmaniasis kinetoplastid proteasome inhibitor for the treatment of visceral leishmaniasis: A Phase 1, randomized, single ascending dose escalation study in healthy participants |
| title_auth | Safety and pharmacokinetics of GSK3494245, a highly selective Leishmaniasis kinetoplastid proteasome inhibitor for the treatment of visceral leishmaniasis: A Phase 1, randomized, single ascending dose escalation study in healthy participants |
| title_full | Safety and pharmacokinetics of GSK3494245, a highly selective Leishmaniasis kinetoplastid proteasome inhibitor for the treatment of visceral leishmaniasis: A Phase 1, randomized, single ascending dose escalation study in healthy participants |
| title_fullStr | Safety and pharmacokinetics of GSK3494245, a highly selective Leishmaniasis kinetoplastid proteasome inhibitor for the treatment of visceral leishmaniasis: A Phase 1, randomized, single ascending dose escalation study in healthy participants |
| title_full_unstemmed | Safety and pharmacokinetics of GSK3494245, a highly selective Leishmaniasis kinetoplastid proteasome inhibitor for the treatment of visceral leishmaniasis: A Phase 1, randomized, single ascending dose escalation study in healthy participants |
| title_short | Safety and pharmacokinetics of GSK3494245, a highly selective Leishmaniasis kinetoplastid proteasome inhibitor for the treatment of visceral leishmaniasis: A Phase 1, randomized, single ascending dose escalation study in healthy participants |
| title_sort | safety and pharmacokinetics of gsk3494245, a highly selective leishmaniasis kinetoplastid proteasome inhibitor for the treatment of visceral leishmaniasis: a phase 1, randomized, single ascending dose escalation study in healthy participants |
| topic | PLOS Neglected Tropical Diseases Atom Clinical Medicine Medical & Health Sciences |
| url | https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0014181 |