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A point mutation in the FAT domain constitutively increases the kinase activity of Rad3ATR and bypasses the requirement for 9-1–1 phosphorylation to activate the DNA replication checkpoint
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| Published in: | PLoS Genetics |
|---|---|
| Format: | Online Article RSS Article |
| Published: |
2026
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| _version_ | 1868847796052819968 |
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| collection | WordPress RSS FRELIP Feed Integration |
| container_title | PLoS Genetics |
| description | |
| discipline_display | Genetics |
| discipline_facet | Genetics |
| format | Online Article RSS Article |
| genre | Journal Article |
| id | rss_article:95085 |
| institution | FRELIP |
| journal_source_facet | PLoS Genetics |
| last_indexed | 2026-06-24T03:35:44.150Z |
| publishDate | 2026 |
| publishDateSort | 2026 |
| record_format | rss_article |
| spellingShingle | A point mutation in the FAT domain constitutively increases the kinase activity of Rad3ATR and bypasses the requirement for 9-1–1 phosphorylation to activate the DNA replication checkpoint Genetics General Genetics |
| sub_discipline_display | General |
| sub_discipline_facet | General |
| subject_display | Genetics General Genetics |
| subject_facet | Genetics General Genetics |
| title | A point mutation in the FAT domain constitutively increases the kinase activity of Rad3ATR and bypasses the requirement for 9-1–1 phosphorylation to activate the DNA replication checkpoint |
| title_alt | Una mutación puntual en el dominio FAT aumenta constitutivamente la actividad quinasa de Rad3ATR y evita el requisito de fosforilación de 9-1-1 para activar el punto de control de replicación del ADN Une mutation ponctuelle dans le domaine FAT augmente constitutivement l'activité kinase de Rad3ATR et contourne l'exigence de phosphorylation de 9-1-1 pour activer le point de contrôle de la réplication de l'ADN Uma mutação pontual no domínio FAT aumenta constitutivamente a atividade quinase de Rad3ATR e contorna a necessidade de fosforilação de 9-1-1 para ativar o checkpoint de replicação do DNA |
| title_auth | A point mutation in the FAT domain constitutively increases the kinase activity of Rad3ATR and bypasses the requirement for 9-1–1 phosphorylation to activate the DNA replication checkpoint |
| title_es_txt | Una mutación puntual en el dominio FAT aumenta constitutivamente la actividad quinasa de Rad3ATR y evita el requisito de fosforilación de 9-1-1 para activar el punto de control de replicación del ADN |
| title_fr_txt | Une mutation ponctuelle dans le domaine FAT augmente constitutivement l'activité kinase de Rad3ATR et contourne l'exigence de phosphorylation de 9-1-1 pour activer le point de contrôle de la réplication de l'ADN |
| title_full | A point mutation in the FAT domain constitutively increases the kinase activity of Rad3ATR and bypasses the requirement for 9-1–1 phosphorylation to activate the DNA replication checkpoint |
| title_fullStr | A point mutation in the FAT domain constitutively increases the kinase activity of Rad3ATR and bypasses the requirement for 9-1–1 phosphorylation to activate the DNA replication checkpoint |
| title_full_unstemmed | A point mutation in the FAT domain constitutively increases the kinase activity of Rad3ATR and bypasses the requirement for 9-1–1 phosphorylation to activate the DNA replication checkpoint |
| title_pt_txt | Uma mutação pontual no domínio FAT aumenta constitutivamente a atividade quinase de Rad3ATR e contorna a necessidade de fosforilação de 9-1-1 para ativar o checkpoint de replicação do DNA |
| title_short | A point mutation in the FAT domain constitutively increases the kinase activity of Rad3ATR and bypasses the requirement for 9-1–1 phosphorylation to activate the DNA replication checkpoint |
| title_sort | a point mutation in the fat domain constitutively increases the kinase activity of rad3atr and bypasses the requirement for 9-1–1 phosphorylation to activate the dna replication checkpoint |
| topic | Genetics General Genetics |
| url | https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1012213 |