Full Text Available
Note: Clicking the button above will open the full text document at the original institutional repository in a new window.
New synthetic routes to functionalized 2-C-alkylglucosides, precursors of potential inhibitors of mycothiol biosynthesis in the Mycobacteria
This thesis was concerned with the design and synthesis of compounds which are either substrate-mimics or inhibitors of MshB, a N-deacetylase involved in the biosynthesis of mycothiol in the Mycobacteria, including M. tuberculosis, the causative agent of TB. Mycothiol is a low molecular weight thiol...
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Chemistry
2015
|
| Subjects: | |
| Tags: |
No Tags, Be the first to tag this record!
|
Similar Items: New synthetic routes to functionalized 2-C-alkylglucosides, precursors of potential inhibitors of mycothiol biosynthesis in the Mycobacteria
- Synthesis of analogues of mycothiol as possible inhibitors of enzymes in the biosynthesis of mycothiol
- Design and synthesis of potential inhibitors of enzymes involved in the biosynthesis and utilisation of mycothiol
- Stereoselective synthesis 2-C-alkylglucosides, potential inhibitors of mycobacterial MshB and related enzymes
- Synthesis of side-chain-modified mycothiol analogues incorporating carbazole quinones, and evaluation as inhibitors of enzymes in the Mycobacteria
- Ferrocenic metal chelators : synthesis, biological and electrochemical studies
- Whole-genome transposon mutagenesis to elucidate the genetic requirements for vitamin B12 biosynthesis and assimilation in mycobacteria