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New synthetic routes to functionalized 2-C-alkylglucosides, precursors of potential inhibitors of mycothiol biosynthesis in the Mycobacteria
This thesis was concerned with the design and synthesis of compounds which are either substrate-mimics or inhibitors of MshB, a N-deacetylase involved in the biosynthesis of mycothiol in the Mycobacteria, including M. tuberculosis, the causative agent of TB. Mycothiol is a low molecular weight thiol...
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| Format: | Thesis |
| Language: | English |
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Department of Chemistry
2015
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| _version_ | 1867613249314226176 |
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| access_status_str | Open Access |
| author | Muganza, Freddy Munyololo |
| author2 | Gammon, David W |
| author_browse | Gammon, David W Muganza, Freddy Munyololo |
| author_facet | Gammon, David W Muganza, Freddy Munyololo |
| author_sort | Muganza, Freddy Munyololo |
| collection | Thesis |
| description | This thesis was concerned with the design and synthesis of compounds which are either substrate-mimics or inhibitors of MshB, a N-deacetylase involved in the biosynthesis of mycothiol in the Mycobacteria, including M. tuberculosis, the causative agent of TB. Mycothiol is a low molecular weight thiol produced by Mycobacteria as a defense against oxidative stress and xenobiotics, and the enzymes involved in its biosynthesis are postulated to be viable drug targets. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/11048 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:08.525Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Department of Chemistry |
| publisherStr | Department of Chemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/11048 New synthetic routes to functionalized 2-C-alkylglucosides, precursors of potential inhibitors of mycothiol biosynthesis in the Mycobacteria Muganza, Freddy Munyololo Gammon, David W Chemistry This thesis was concerned with the design and synthesis of compounds which are either substrate-mimics or inhibitors of MshB, a N-deacetylase involved in the biosynthesis of mycothiol in the Mycobacteria, including M. tuberculosis, the causative agent of TB. Mycothiol is a low molecular weight thiol produced by Mycobacteria as a defense against oxidative stress and xenobiotics, and the enzymes involved in its biosynthesis are postulated to be viable drug targets. 2015-01-02T09:26:27Z 2015-01-02T09:26:27Z 2011 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/11048 eng application/pdf Department of Chemistry Faculty of Science University of Cape Town |
| spellingShingle | Chemistry Muganza, Freddy Munyololo New synthetic routes to functionalized 2-C-alkylglucosides, precursors of potential inhibitors of mycothiol biosynthesis in the Mycobacteria |
| thesis_degree_str | Doctoral |
| title | New synthetic routes to functionalized 2-C-alkylglucosides, precursors of potential inhibitors of mycothiol biosynthesis in the Mycobacteria |
| title_full | New synthetic routes to functionalized 2-C-alkylglucosides, precursors of potential inhibitors of mycothiol biosynthesis in the Mycobacteria |
| title_fullStr | New synthetic routes to functionalized 2-C-alkylglucosides, precursors of potential inhibitors of mycothiol biosynthesis in the Mycobacteria |
| title_full_unstemmed | New synthetic routes to functionalized 2-C-alkylglucosides, precursors of potential inhibitors of mycothiol biosynthesis in the Mycobacteria |
| title_short | New synthetic routes to functionalized 2-C-alkylglucosides, precursors of potential inhibitors of mycothiol biosynthesis in the Mycobacteria |
| title_sort | new synthetic routes to functionalized 2 c alkylglucosides precursors of potential inhibitors of mycothiol biosynthesis in the mycobacteria |
| topic | Chemistry |
| url | http://hdl.handle.net/11427/11048 |
| work_keys_str_mv | AT muganzafreddymunyololo newsyntheticroutestofunctionalized2calkylglucosidesprecursorsofpotentialinhibitorsofmycothiolbiosynthesisinthemycobacteria |