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The relationship between structure and specificity in the plant nitrilases
Nitrilases (EC 3.5.5.1) catalyse the enantioselective hydrolysis of a variety of organic nitriles to the corresponding amide and/ or carboxylic acid. These reactions are important in the manufacture of fine chemicals, pharmaceutical intermediates, plastics and paints. Industrial uses of nitrilases a...
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| Format: | Thesis |
| Language: | English |
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Department of Molecular and Cell Biology
2015
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| Summary: | Nitrilases (EC 3.5.5.1) catalyse the enantioselective hydrolysis of a variety of organic nitriles to the corresponding amide and/ or carboxylic acid. These reactions are important in the manufacture of fine chemicals, pharmaceutical intermediates, plastics and paints. Industrial uses of nitrilases are limited however, as wild-type enzymes suffer from limitations such as: a lack of control of the acid:amide ratio of products, and limited availability of substrate specificities. |
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