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The relationship between structure and specificity in the plant nitrilases
Nitrilases (EC 3.5.5.1) catalyse the enantioselective hydrolysis of a variety of organic nitriles to the corresponding amide and/ or carboxylic acid. These reactions are important in the manufacture of fine chemicals, pharmaceutical intermediates, plastics and paints. Industrial uses of nitrilases a...
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| Format: | Thesis |
| Language: | English |
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Department of Molecular and Cell Biology
2015
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| _version_ | 1867613154800828416 |
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| access_status_str | Open Access |
| author | Woodward, Jeremy David |
| author2 | Sewell, Trevor |
| author_browse | Sewell, Trevor Woodward, Jeremy David |
| author_facet | Sewell, Trevor Woodward, Jeremy David |
| author_sort | Woodward, Jeremy David |
| collection | Thesis |
| description | Nitrilases (EC 3.5.5.1) catalyse the enantioselective hydrolysis of a variety of organic nitriles to the corresponding amide and/ or carboxylic acid. These reactions are important in the manufacture of fine chemicals, pharmaceutical intermediates, plastics and paints. Industrial uses of nitrilases are limited however, as wild-type enzymes suffer from limitations such as: a lack of control of the acid:amide ratio of products, and limited availability of substrate specificities. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/11347 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:31:38.662Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Department of Molecular and Cell Biology |
| publisherStr | Department of Molecular and Cell Biology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/11347 The relationship between structure and specificity in the plant nitrilases Woodward, Jeremy David Sewell, Trevor Cell Biology Nitrilases (EC 3.5.5.1) catalyse the enantioselective hydrolysis of a variety of organic nitriles to the corresponding amide and/ or carboxylic acid. These reactions are important in the manufacture of fine chemicals, pharmaceutical intermediates, plastics and paints. Industrial uses of nitrilases are limited however, as wild-type enzymes suffer from limitations such as: a lack of control of the acid:amide ratio of products, and limited availability of substrate specificities. 2015-01-05T06:46:57Z 2015-01-05T06:46:57Z 2011 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/11347 eng application/pdf Department of Molecular and Cell Biology Faculty of Science University of Cape Town |
| spellingShingle | Cell Biology Woodward, Jeremy David The relationship between structure and specificity in the plant nitrilases |
| thesis_degree_str | Doctoral |
| title | The relationship between structure and specificity in the plant nitrilases |
| title_full | The relationship between structure and specificity in the plant nitrilases |
| title_fullStr | The relationship between structure and specificity in the plant nitrilases |
| title_full_unstemmed | The relationship between structure and specificity in the plant nitrilases |
| title_short | The relationship between structure and specificity in the plant nitrilases |
| title_sort | relationship between structure and specificity in the plant nitrilases |
| topic | Cell Biology |
| url | http://hdl.handle.net/11427/11347 |
| work_keys_str_mv | AT woodwardjeremydavid therelationshipbetweenstructureandspecificityintheplantnitrilases AT woodwardjeremydavid relationshipbetweenstructureandspecificityintheplantnitrilases |