Full Text Available
Note: Clicking the button above will open the full text document at the original institutional repository in a new window.
The role of Toll-like receptor 4 (TLR-4) in wine-induced cardioprotection
Includes abstract.
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Medicine
2015
|
| Subjects: | |
| Tags: |
No Tags, Be the first to tag this record!
|
| _version_ | 1867613195834753024 |
|---|---|
| access_status_str | Open Access |
| author | Albertyn, Zulfah |
| author2 | Lecour, Sandrine |
| author_browse | Albertyn, Zulfah Lecour, Sandrine |
| author_facet | Lecour, Sandrine Albertyn, Zulfah |
| author_sort | Albertyn, Zulfah |
| collection | Thesis |
| description | Includes abstract. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/11789 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:17.361Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Department of Medicine |
| publisherStr | Department of Medicine |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/11789 The role of Toll-like receptor 4 (TLR-4) in wine-induced cardioprotection Albertyn, Zulfah Lecour, Sandrine Opie, Lionel H MED Includes abstract. Includes bibliographical references. Moderate and chronic consumption of red wine confers cardioprotection. Melatonin, present in wine, may contribute to this cardioprotective effect. Melatonin confers cardioprotection via the activation of tumor necrosis factoralpha (TNF-α) and the signal transducer and activator of transcription-3(STAT-3), via mechanisms that still remain to be delineated. We therefore hypothesise that South African red and white wines confer a cardioprotective effect in relation to their melatonin content. Furthermore, we propose that the cardioprotective effect of melatonin (at a concentration found in red wine) is dependent on the activation of Toll-like receptor 4 (TLR-4) to activate TNF-α/STAT-3. 2015-01-08T20:00:35Z 2015-01-08T20:00:35Z 2012 Master Thesis Masters MSc http://hdl.handle.net/11427/11789 eng application/pdf Department of Medicine Faculty of Health Sciences University of Cape Town |
| spellingShingle | MED Albertyn, Zulfah The role of Toll-like receptor 4 (TLR-4) in wine-induced cardioprotection |
| thesis_degree_str | Master's |
| title | The role of Toll-like receptor 4 (TLR-4) in wine-induced cardioprotection |
| title_full | The role of Toll-like receptor 4 (TLR-4) in wine-induced cardioprotection |
| title_fullStr | The role of Toll-like receptor 4 (TLR-4) in wine-induced cardioprotection |
| title_full_unstemmed | The role of Toll-like receptor 4 (TLR-4) in wine-induced cardioprotection |
| title_short | The role of Toll-like receptor 4 (TLR-4) in wine-induced cardioprotection |
| title_sort | role of toll like receptor 4 tlr 4 in wine induced cardioprotection |
| topic | MED |
| url | http://hdl.handle.net/11427/11789 |
| work_keys_str_mv | AT albertynzulfah theroleoftolllikereceptor4tlr4inwineinducedcardioprotection AT albertynzulfah roleoftolllikereceptor4tlr4inwineinducedcardioprotection |