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Supramolecular modification of selected antiretroviral drugs
Includes bibliographical references.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
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Department of Chemistry
2015
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| _version_ | 1867613862492110848 |
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| access_status_str | Open Access |
| author | Engel, Emile Richard |
| author2 | Caira, Mino R |
| author_browse | Caira, Mino R Engel, Emile Richard |
| author_facet | Caira, Mino R Engel, Emile Richard |
| author_sort | Engel, Emile Richard |
| collection | Thesis |
| description | Includes bibliographical references. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/12675 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:42:53.623Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Department of Chemistry |
| publisherStr | Department of Chemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/12675 Supramolecular modification of selected antiretroviral drugs Engel, Emile Richard Caira, Mino R Bourne, Susan Chemistry Includes bibliographical references. A number of antiretroviral drugs that are currently in use for anti-HIV therapy have extremely poor aqueous solubility. This, along with the fact that many of these pharmaceutical compounds possess potential hydrogen bond donor and acceptor functionalities, makes them ideal candidates for attempted supramolecular derivatisation. The primary objective of this study was to carry out cocrystal screening and attempt cyclodextrin complexation with nevirapine, efavirenz, lamivudine and zidovudine, with a view to identifying and isolating new solid forms of these drugs. Any new forms were to be characterised by a variety of analytical techniques, including thermal, spectroscopic and X-ray analysis and, where possible, such derivatives would be tested for any enhancements of drug solubility. 2015-04-02T14:18:25Z 2015-04-02T14:18:25Z 2011 Master Thesis Masters MSc http://hdl.handle.net/11427/12675 eng application/pdf Department of Chemistry Faculty of Science University of Cape Town |
| spellingShingle | Chemistry Engel, Emile Richard Supramolecular modification of selected antiretroviral drugs |
| thesis_degree_str | Master's |
| title | Supramolecular modification of selected antiretroviral drugs |
| title_full | Supramolecular modification of selected antiretroviral drugs |
| title_fullStr | Supramolecular modification of selected antiretroviral drugs |
| title_full_unstemmed | Supramolecular modification of selected antiretroviral drugs |
| title_short | Supramolecular modification of selected antiretroviral drugs |
| title_sort | supramolecular modification of selected antiretroviral drugs |
| topic | Chemistry |
| url | http://hdl.handle.net/11427/12675 |
| work_keys_str_mv | AT engelemilerichard supramolecularmodificationofselectedantiretroviraldrugs |