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Computer-aided chemical speciation in metal-based drug design
Formation constants of Cu²⁺, Ni²⁺, Zn²⁺, Ca²⁺ and Gd³⁺ with the polyamine(amide) ligands N,N' -bis(2-hydroxyiminopropionyl) propane-1,3-diamine (L² ) and (1, 15)- bis(N,N-dimethyl)-5, 11-dioxo-8-(N-benzyl)-l ,4,8, 12, 15-pentaazapentadecane (L³ ) as well as those of Gd³⁺ with 3,3,9,9-tetramethyl-4,8...
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| Format: | Thesis |
| Language: | English |
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Department of Chemistry
2016
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| _version_ | 1867614218942939136 |
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| access_status_str | Open Access |
| author | Nomkoko, Thembelani Edmund |
| author2 | Jackson, Graham Ellis |
| author_browse | Jackson, Graham Ellis Nomkoko, Thembelani Edmund |
| author_facet | Jackson, Graham Ellis Nomkoko, Thembelani Edmund |
| author_sort | Nomkoko, Thembelani Edmund |
| collection | Thesis |
| description | Formation constants of Cu²⁺, Ni²⁺, Zn²⁺, Ca²⁺ and Gd³⁺ with the polyamine(amide) ligands N,N' -bis(2-hydroxyiminopropionyl) propane-1,3-diamine (L² ) and (1, 15)- bis(N,N-dimethyl)-5, 11-dioxo-8-(N-benzyl)-l ,4,8, 12, 15-pentaazapentadecane (L³ ) as well as those of Gd³⁺ with 3,3,9,9-tetramethyl-4,8-diazaundecane-2,10-dione dioxime (L 1 ) were investigated by glass electrode potentiometry at 25°C and an ionic strength (I) of 0.15 mol dm-³. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/21347 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:48:33.561Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2016 |
| publishDateRange | 2016 |
| publishDateSort | 2016 |
| publisher | Department of Chemistry |
| publisherStr | Department of Chemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/21347 Computer-aided chemical speciation in metal-based drug design Nomkoko, Thembelani Edmund Jackson, Graham Ellis Chemistry Formation constants of Cu²⁺, Ni²⁺, Zn²⁺, Ca²⁺ and Gd³⁺ with the polyamine(amide) ligands N,N' -bis(2-hydroxyiminopropionyl) propane-1,3-diamine (L² ) and (1, 15)- bis(N,N-dimethyl)-5, 11-dioxo-8-(N-benzyl)-l ,4,8, 12, 15-pentaazapentadecane (L³ ) as well as those of Gd³⁺ with 3,3,9,9-tetramethyl-4,8-diazaundecane-2,10-dione dioxime (L 1 ) were investigated by glass electrode potentiometry at 25°C and an ionic strength (I) of 0.15 mol dm-³. 2016-08-18T13:57:19Z 2016-08-18T13:57:19Z 2002 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/21347 eng application/pdf Department of Chemistry Faculty of Science University of Cape Town |
| spellingShingle | Chemistry Nomkoko, Thembelani Edmund Computer-aided chemical speciation in metal-based drug design |
| thesis_degree_str | Doctoral |
| title | Computer-aided chemical speciation in metal-based drug design |
| title_full | Computer-aided chemical speciation in metal-based drug design |
| title_fullStr | Computer-aided chemical speciation in metal-based drug design |
| title_full_unstemmed | Computer-aided chemical speciation in metal-based drug design |
| title_short | Computer-aided chemical speciation in metal-based drug design |
| title_sort | computer aided chemical speciation in metal based drug design |
| topic | Chemistry |
| url | http://hdl.handle.net/11427/21347 |
| work_keys_str_mv | AT nomkokothembelaniedmund computeraidedchemicalspeciationinmetalbaseddrugdesign |