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The role of haem in the mechanism of action of antimalarials in Plasmodium falciparum
The malaria parasite detoxifies host red blood cell derived haem by conversion into the inert biocrystal haemozoin. Inhibiting this critical pathway is proposed to be the mechanism of action of chloroquine and related antimalarials and several studies have linked inhibition of the formation of synth...
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| Format: | Thesis |
| Language: | English |
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Division of Clinical Pharmacology
2017
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| _version_ | 1867614482513002496 |
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| access_status_str | Open Access |
| author | Combrinck, Jill Michelle |
| author2 | Egan, Timothy J |
| author_browse | Combrinck, Jill Michelle Egan, Timothy J |
| author_facet | Egan, Timothy J Combrinck, Jill Michelle |
| author_sort | Combrinck, Jill Michelle |
| collection | Thesis |
| description | The malaria parasite detoxifies host red blood cell derived haem by conversion into the inert biocrystal haemozoin. Inhibiting this critical pathway is proposed to be the mechanism of action of chloroquine and related antimalarials and several studies have linked inhibition of the formation of synthetic haemozoin, β-haematin, to parasite survival. However, haemozoin inhibition with a dose related increase in "free" haem correlated to decreased survival has not been demonstrated in the parasite. This project investigated the role of haem in the mechanism of action of several clinically relevant and novel antimalarials in the malaria parasite, Plasmodium falciparum. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/22760 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:52:44.921Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2017 |
| publishDateRange | 2017 |
| publishDateSort | 2017 |
| publisher | Division of Clinical Pharmacology |
| publisherStr | Division of Clinical Pharmacology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/22760 The role of haem in the mechanism of action of antimalarials in Plasmodium falciparum Combrinck, Jill Michelle Egan, Timothy J Smith, Peter Pharmacology The malaria parasite detoxifies host red blood cell derived haem by conversion into the inert biocrystal haemozoin. Inhibiting this critical pathway is proposed to be the mechanism of action of chloroquine and related antimalarials and several studies have linked inhibition of the formation of synthetic haemozoin, β-haematin, to parasite survival. However, haemozoin inhibition with a dose related increase in "free" haem correlated to decreased survival has not been demonstrated in the parasite. This project investigated the role of haem in the mechanism of action of several clinically relevant and novel antimalarials in the malaria parasite, Plasmodium falciparum. 2017-01-17T12:23:31Z 2017-01-17T12:23:31Z 2016 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/22760 eng application/pdf Division of Clinical Pharmacology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Pharmacology Combrinck, Jill Michelle The role of haem in the mechanism of action of antimalarials in Plasmodium falciparum |
| thesis_degree_str | Doctoral |
| title | The role of haem in the mechanism of action of antimalarials in Plasmodium falciparum |
| title_full | The role of haem in the mechanism of action of antimalarials in Plasmodium falciparum |
| title_fullStr | The role of haem in the mechanism of action of antimalarials in Plasmodium falciparum |
| title_full_unstemmed | The role of haem in the mechanism of action of antimalarials in Plasmodium falciparum |
| title_short | The role of haem in the mechanism of action of antimalarials in Plasmodium falciparum |
| title_sort | role of haem in the mechanism of action of antimalarials in plasmodium falciparum |
| topic | Pharmacology |
| url | http://hdl.handle.net/11427/22760 |
| work_keys_str_mv | AT combrinckjillmichelle theroleofhaeminthemechanismofactionofantimalarialsinplasmodiumfalciparum AT combrinckjillmichelle roleofhaeminthemechanismofactionofantimalarialsinplasmodiumfalciparum |