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The role of haem in the mechanism of action of antimalarials in Plasmodium falciparum
The malaria parasite detoxifies host red blood cell derived haem by conversion into the inert biocrystal haemozoin. Inhibiting this critical pathway is proposed to be the mechanism of action of chloroquine and related antimalarials and several studies have linked inhibition of the formation of synth...
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| Format: | Thesis |
| Language: | English |
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Division of Clinical Pharmacology
2017
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