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The interaction of xenobiotics and anaesthetic agents with hepatic microsomal stearate desaturase
This thesis comprises an investigation into the reaction of halogenated xenobiotics and anaesthetic agents, with hepatic microsomal stearate desaturase. The levels of stearate desaturase in the hepatic microsomes were routinely elevated by re-feeding the experimental animals a high carbohydrate diet...
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Division of Medical Biochemistry and Structural Biology
2018
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| _version_ | 1867613295860514816 |
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| access_status_str | Open Access |
| author | Manca, Veronica |
| author2 | Harrison, Gaisford Gerald |
| author_browse | Harrison, Gaisford Gerald Manca, Veronica |
| author_facet | Harrison, Gaisford Gerald Manca, Veronica |
| author_sort | Manca, Veronica |
| collection | Thesis |
| description | This thesis comprises an investigation into the reaction of halogenated xenobiotics and anaesthetic agents, with hepatic microsomal stearate desaturase. The levels of stearate desaturase in the hepatic microsomes were routinely elevated by re-feeding the experimental animals a high carbohydrate diet. The interaction of the xenobiotics with stearate desaturase was assessed by monitoring their effects on the redox steady state of hepatic microsomal cytochrome b₅, in the presence and absence of cyanide. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/27512 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:33:51.607Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2018 |
| publishDateRange | 2018 |
| publishDateSort | 2018 |
| publisher | Division of Medical Biochemistry and Structural Biology |
| publisherStr | Division of Medical Biochemistry and Structural Biology |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/27512 The interaction of xenobiotics and anaesthetic agents with hepatic microsomal stearate desaturase Manca, Veronica Harrison, Gaisford Gerald Ivanetich, Kathryn M Microsomes, Liver Stearic acids Anaesthetics This thesis comprises an investigation into the reaction of halogenated xenobiotics and anaesthetic agents, with hepatic microsomal stearate desaturase. The levels of stearate desaturase in the hepatic microsomes were routinely elevated by re-feeding the experimental animals a high carbohydrate diet. The interaction of the xenobiotics with stearate desaturase was assessed by monitoring their effects on the redox steady state of hepatic microsomal cytochrome b₅, in the presence and absence of cyanide. 2018-02-12T08:45:10Z 2018-02-12T08:45:10Z 1980 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/27512 eng application/pdf Division of Medical Biochemistry and Structural Biology Faculty of Health Sciences University of Cape Town |
| spellingShingle | Microsomes, Liver Stearic acids Anaesthetics Manca, Veronica The interaction of xenobiotics and anaesthetic agents with hepatic microsomal stearate desaturase |
| thesis_degree_str | Doctoral |
| title | The interaction of xenobiotics and anaesthetic agents with hepatic microsomal stearate desaturase |
| title_full | The interaction of xenobiotics and anaesthetic agents with hepatic microsomal stearate desaturase |
| title_fullStr | The interaction of xenobiotics and anaesthetic agents with hepatic microsomal stearate desaturase |
| title_full_unstemmed | The interaction of xenobiotics and anaesthetic agents with hepatic microsomal stearate desaturase |
| title_short | The interaction of xenobiotics and anaesthetic agents with hepatic microsomal stearate desaturase |
| title_sort | interaction of xenobiotics and anaesthetic agents with hepatic microsomal stearate desaturase |
| topic | Microsomes, Liver Stearic acids Anaesthetics |
| url | http://hdl.handle.net/11427/27512 |
| work_keys_str_mv | AT mancaveronica theinteractionofxenobioticsandanaestheticagentswithhepaticmicrosomalstearatedesaturase AT mancaveronica interactionofxenobioticsandanaestheticagentswithhepaticmicrosomalstearatedesaturase |