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The effect of boundary conditions and architecture on the response of cancellous bone
The investigation presented herein was performed to determine the effect of boundary conditions and architectural parameters on the mechanical properties of bovine cancellous bone. 124 cylindrical cancellous samples (7.5 mm height) were harvested from a total of 9 bovine humeri. Mechanical propertie...
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| Format: | Thesis |
| Language: | English |
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Department of Mechanical Engineering
2019
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| _version_ | 1867613226088267776 |
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| access_status_str | Open Access |
| author | Hilton, Kelsey |
| author2 | Cloete,Trevor |
| author_browse | Cloete,Trevor Hilton, Kelsey |
| author_facet | Cloete,Trevor Hilton, Kelsey |
| author_sort | Hilton, Kelsey |
| collection | Thesis |
| description | The investigation presented herein was performed to determine the effect of boundary conditions and architectural parameters on the mechanical properties of bovine cancellous bone. 124 cylindrical cancellous samples (7.5 mm height) were harvested from a total of 9 bovine humeri. Mechanical properties of these samples were determined using compression tests performed at three, quasi-static strain rates, namely: 10−3 , 10−2 and 10−1 s −1 .The specimen conditions investigated were standard specimens (with marrow, 10 mm diameter), defatted specimens (without marrow, 10 mm diameter), structurally confined specimens (with marrow and a confining collar, 10 mm diameter) and bone confined specimens (with marrow, 20 mm and 28 mm diameters). Each specimen was scanned using a µCT scanner (Phoenix, voxel size 80 µm, 70 kV, 350 µA, acquisition time of 500 ms per image). The images were used to determine the architectural parameters for each specimen, which were calculated using algorithms developed during the study. These algorithms were validated against existing software (BoneJ) which is available to calculate cancellous bone architectural parameters. The results of the compression testing showed little dependence of mechanical properties on strain rate. The results of the defatted and structurally confined specimens showed a decrease in scatter with the elimination and reduction, respectively, of flow of the marrow within the trabecular network. This suggests that although marrow does not strengthen bone at quasi-static strain rates, the flow of marrow disrupts the trabecular network. The bone confinement results showed significantly increased mechanical strength of the inner 10 mm core compared to the whole sample. Apparent modulus was found to be 58% and 60% higher in the central core of the sample for 20 mm and 28 mm samples respectively. This suggests that doubling the diameter effectively removes the edge effects, with any additional diameter increase having no effect. Inner core yield strength was 58% higher in the 20 mm samples, and roughly 96% higher in the 28 mm samples compared to full specimen yield strength. This suggested that post-yield behaviour requires a further increase in overall diameter to sufficiently remove the edge effects due to the boundary condition. University of Cape Town Department of Mechanical Engineering The results of the architectural parameters suggested a linear correlation between the mechanical properties and parameters bone volume versus total volume and trabecular number. An exponential relationship was found to exist between the mechanical properties and mean trabecular separation. No correlation was found between mechanical properties and mean trabecular thickness. It was also concluded that specimen condition affects the relationship between mechanical properties and architectural parameters. Therefore, to effectively predict the response of cancellous bone, specimen condition should be used in conjunction with at least two architectural parameters, preferably bone volume versus total volume and mean trabecular separation. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/29542 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:32:46.693Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2019 |
| publishDateRange | 2019 |
| publishDateSort | 2019 |
| publisher | Department of Mechanical Engineering |
| publisherStr | Department of Mechanical Engineering |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/29542 The effect of boundary conditions and architecture on the response of cancellous bone Hilton, Kelsey Cloete,Trevor Mechanical Engineering The investigation presented herein was performed to determine the effect of boundary conditions and architectural parameters on the mechanical properties of bovine cancellous bone. 124 cylindrical cancellous samples (7.5 mm height) were harvested from a total of 9 bovine humeri. Mechanical properties of these samples were determined using compression tests performed at three, quasi-static strain rates, namely: 10−3 , 10−2 and 10−1 s −1 .The specimen conditions investigated were standard specimens (with marrow, 10 mm diameter), defatted specimens (without marrow, 10 mm diameter), structurally confined specimens (with marrow and a confining collar, 10 mm diameter) and bone confined specimens (with marrow, 20 mm and 28 mm diameters). Each specimen was scanned using a µCT scanner (Phoenix, voxel size 80 µm, 70 kV, 350 µA, acquisition time of 500 ms per image). The images were used to determine the architectural parameters for each specimen, which were calculated using algorithms developed during the study. These algorithms were validated against existing software (BoneJ) which is available to calculate cancellous bone architectural parameters. The results of the compression testing showed little dependence of mechanical properties on strain rate. The results of the defatted and structurally confined specimens showed a decrease in scatter with the elimination and reduction, respectively, of flow of the marrow within the trabecular network. This suggests that although marrow does not strengthen bone at quasi-static strain rates, the flow of marrow disrupts the trabecular network. The bone confinement results showed significantly increased mechanical strength of the inner 10 mm core compared to the whole sample. Apparent modulus was found to be 58% and 60% higher in the central core of the sample for 20 mm and 28 mm samples respectively. This suggests that doubling the diameter effectively removes the edge effects, with any additional diameter increase having no effect. Inner core yield strength was 58% higher in the 20 mm samples, and roughly 96% higher in the 28 mm samples compared to full specimen yield strength. This suggested that post-yield behaviour requires a further increase in overall diameter to sufficiently remove the edge effects due to the boundary condition. University of Cape Town Department of Mechanical Engineering The results of the architectural parameters suggested a linear correlation between the mechanical properties and parameters bone volume versus total volume and trabecular number. An exponential relationship was found to exist between the mechanical properties and mean trabecular separation. No correlation was found between mechanical properties and mean trabecular thickness. It was also concluded that specimen condition affects the relationship between mechanical properties and architectural parameters. Therefore, to effectively predict the response of cancellous bone, specimen condition should be used in conjunction with at least two architectural parameters, preferably bone volume versus total volume and mean trabecular separation. 2019-02-14T16:21:56Z 2019-02-14T16:21:56Z 2018 2019-02-11T08:25:17Z Master Thesis Masters MSc http://hdl.handle.net/11427/29542 eng application/pdf Department of Mechanical Engineering Faculty of Engineering and the Built Environment University of Cape Town |
| spellingShingle | Mechanical Engineering Hilton, Kelsey The effect of boundary conditions and architecture on the response of cancellous bone |
| thesis_degree_str | Master's |
| title | The effect of boundary conditions and architecture on the response of cancellous bone |
| title_full | The effect of boundary conditions and architecture on the response of cancellous bone |
| title_fullStr | The effect of boundary conditions and architecture on the response of cancellous bone |
| title_full_unstemmed | The effect of boundary conditions and architecture on the response of cancellous bone |
| title_short | The effect of boundary conditions and architecture on the response of cancellous bone |
| title_sort | effect of boundary conditions and architecture on the response of cancellous bone |
| topic | Mechanical Engineering |
| url | http://hdl.handle.net/11427/29542 |
| work_keys_str_mv | AT hiltonkelsey theeffectofboundaryconditionsandarchitectureontheresponseofcancellousbone AT hiltonkelsey effectofboundaryconditionsandarchitectureontheresponseofcancellousbone |