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Rationalising the effect of guanine-based Ricin inhibitors using computer simulations
Includes abstract.
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| Main Author: | |
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
| Published: |
Department of Chemistry
2014
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| _version_ | 1867613495879532544 |
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| access_status_str | Open Access |
| author | Jayakody, Ranga S |
| author2 | Naidoo, Kevin J |
| author_browse | Jayakody, Ranga S Naidoo, Kevin J |
| author_facet | Naidoo, Kevin J Jayakody, Ranga S |
| author_sort | Jayakody, Ranga S |
| collection | Thesis |
| description | Includes abstract. |
| format | Thesis |
| id | oai:open.uct.ac.za:11427/6315 |
| institution | University of Cape Town (South Africa) |
| language | eng |
| last_indexed | 2026-06-10T12:37:03.994Z |
| license_str | Not specified — see source repository |
| provenance_str_mv | Harvested via OAI-PMH from UCTD — University of Cape Town Open Access Repository |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Department of Chemistry |
| publisherStr | Department of Chemistry |
| record_format | dspace |
| source_str | UCTD — University of Cape Town Open Access Repository |
| spelling | oai:open.uct.ac.za:11427/6315 Rationalising the effect of guanine-based Ricin inhibitors using computer simulations Jayakody, Ranga S Naidoo, Kevin J Chemistry Includes abstract. Includes bibliographical references (leaves 99-101). for humans.This has lead to its use as a biological weapon and a therapeutic agent. the reaction mechanism of ricin is not known and so rational design is limited, resulting in no effective inhibitor being found for this enzyme. An important step towards understanding the reaction mechanism and the design of effective inhibitors is the complete understanding of the binding pocket and the mode/nature of binding ligands to the protein. In this thesis computational methods were used to rationalise the effect of selected ricin inhibitors. 2014-08-13T14:26:36Z 2014-08-13T14:26:36Z 2008 Master Thesis Masters MSc http://hdl.handle.net/11427/6315 eng application/pdf Department of Chemistry Faculty of Science University of Cape Town |
| spellingShingle | Chemistry Jayakody, Ranga S Rationalising the effect of guanine-based Ricin inhibitors using computer simulations |
| thesis_degree_str | Master's |
| title | Rationalising the effect of guanine-based Ricin inhibitors using computer simulations |
| title_full | Rationalising the effect of guanine-based Ricin inhibitors using computer simulations |
| title_fullStr | Rationalising the effect of guanine-based Ricin inhibitors using computer simulations |
| title_full_unstemmed | Rationalising the effect of guanine-based Ricin inhibitors using computer simulations |
| title_short | Rationalising the effect of guanine-based Ricin inhibitors using computer simulations |
| title_sort | rationalising the effect of guanine based ricin inhibitors using computer simulations |
| topic | Chemistry |
| url | http://hdl.handle.net/11427/6315 |
| work_keys_str_mv | AT jayakodyrangas rationalisingtheeffectofguaninebasedricininhibitorsusingcomputersimulations |