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Construction and analysis of a kinetic model of the ovine adrenal steroidogenic subsystem comprising of CYP17 and 3β-HSD
ENGLISH ABSTRACT : This study describes: how time-dependent experimental data, describing the reactions catalyzed by ovine cytochrome P450 17α-hydroxylase/17,20-lyase (CYP17), was obtained using pregnenolone and progesterone as substrates ; the construction and validation of a kinetic model and...
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| Format: | Thesis |
| Language: | en_ZA |
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Stellenbosch : Stellenbosch University
2016
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| Summary: | ENGLISH ABSTRACT : This study describes: how time-dependent experimental data, describing the reactions catalyzed by ovine
cytochrome P450 17α-hydroxylase/17,20-lyase (CYP17), was obtained using
pregnenolone and progesterone as substrates ;
the construction and validation of a kinetic model and determining the Km and Vmax -
values for each reaction catalyzed by ovine CYP17 ; how the time-dependent metabolism of pregnenolone, 17α-hydroxypregnenolone and
dehydroepiandrosterone by ovine 3β-hydroxysteroid dehydrogenase (3β-HSD), was
obtained ;
the construction and validation of a kinetic model and determining the Km and Vmax -
values for each reaction catalyzed by ovine 3β-HSD |
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